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Neousys MezIO-C181-50 8-Port Serial MezIO Module with 4x RS-232/422/485 and 4x RS-422/485

The MezIO-C181-50 is the RS-422/485 module in the Neousys MezIO-C180/C181 series: an eight-port serial MezIO module with four RS-232/422/485 multi-mode ports and four RS-422/485 ports on one SCSI-II 68-pin connector. It suits RS-485 meter and drive networks that still need some RS-232 for older devices.

  • Four RS-422/485 Ports Plus Four Multi-Mode: Four dedicated RS-422/485 ports join four RS-232/422/485 ports, giving up to eight differential serial links from one module.
  • Up to 921.6 Kbps on Every Port: Baud rates run from 50 bps to 921.6 Kbps, and each port has 256-byte TX and RX FIFOs to buffer traffic.
  • RS-232 Where You Still Need It: Mode and termination on the four multi-mode ports are set in the BIOS, so RS-232 stays available for a legacy device.
  • ESD Protection and Full Signal Set: Each port has ESD protection, with RS-422 TxD+/- and RxD+/- or RS-485 Data+/- on the differential ports.
  • SCSI-II 68-Pin Connector to DB-9: All eight ports share one 68-pin SCSI-II female connector, broken out to eight DB-9 male plugs by a 50 cm cable.
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MezIO-C181-50 Overview

Many serial networks on a plant are differential rather than RS-232: power meters, drives and remote I/O on an RS-485 bus, or RS-422 links that run further than RS-232 typically allows. The MezIO-C181-50 is part of the Neousys MezIO-C180/C181 serial module family, and it is the version built around RS-422 and RS-485 for that kind of wiring.

The module adds four RS-422/485 ports and four RS-232/422/485 multi-mode ports to the host computer. Every port runs from 50 bps to 921.6 Kbps with 256-byte TX and RX FIFOs and ESD protection, and mode and termination on the multi-mode ports are set in the BIOS. That means one MezIO-C181-50 can run up to eight differential links, or keep a few ports on RS-232 for an older instrument. Windows 10 and Linux are supported. If most of your devices are RS-232, the MezIO-C180-50 keeps four multi-mode ports and adds four RS-232 ports instead.

We fit the MezIO-C181-50 inside the Neousys system on its high-speed board-to-board connector with three-point mezzanine mounting, then configure the port modes and termination and test the build before it ships. There is one MezIO interface per system. The module fits the Nuvo-9000, Nuvo-11000, Nuvo-11160GC, Nuvo-9160GC and Nuvo-9166GC series, and the POC-900, POC-700, POC-700-FT and POC-600 compact computers.

The eight ports share one 68-pin SCSI-II female connector on the system. Bringing all eight ports out on one connector keeps the cabling at the computer to a single run for your bus wiring or terminal blocks. On the RS-232 side, the multi-mode ports carry TxD, RxD, RTS, CTS, DTR, DSR, DCD and GND. If you send us the device list and the bus layout, we can suggest which ports to run in which mode.

MezIO-C181-50 Specifications

Overview
Brand & ModelNeousys MezIO-C181-50
Performance
Operating SystemLinux
Windows 10
I/O
Serial8x Serial Ports
4x RS232/422/485 [SCSI-68]
4x RS422/485 [SCSI-68]

MezIO-C181-50 Compatible Systems

MezIO-C181-50 fits the Neousys systems below. We fit and test the module inside the system before it ships. Each card shows the models in that series the module fits.

  • CPU: Intel Core 12th Gen Alder Lake, Intel Core 13th Gen Raptor Lake
  • Memory: 2x DDR5 4800MHz SO-DIMM Slot, 64GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 1x Display Port, 1x DVI, 1x VGA
  • USB: 1x USB 3.2 Gen 2x2 [Type C], 2x USB 2.0 [Type A], 2x USB 3.2 Gen 1 [Type A], 4x USB 3.2 Gen 2 [Type A]
  • Serial: 2x RS232 [DB9], 2x RS232/422/485 [DB9]
  • M.2: 1x M.2 B-Key [PCIe x1/USB/SIM] [2242/3052], 1x M.2 M-Key [PCIe x4 Gen4] [2280]
  • mPCIe: 1x mPCIe [PCIe/USB]
  • Storage: 1x M.2 SSD [M-Key 2280, PCIe Gen 4 x4], 2x 2.5" HDD/SSD [SATA]
  • RAID: RAID 0, RAID 1
  • Ignition Sensing: Supports Ignition Control
  • Temp: -25°C to 70°C [-13°F to 158°F]
  • Mounting Options: DIN Mount, Wall Mount
  • Ethernet: 1x 2.5 GbE LAN [RJ45], 1x GbE LAN [RJ45]
  • PCIe: 1x PCIe [x16 Slot] [x8 Signal] [Gen3]
  • Power: 8-48V DC [Terminal Block]
  • Certification: CE, FCC
COMPARE VARIANTS
Select Nuvo-9000 Variant
Nuvo-9002DE : NUVO-9000 with dual-slot PCIe Cassette, 2.5GbE plus GbE
Nuvo-9002DE-UL : NUVO-9000 with dual-slot PCIe Cassette, 2.5GbE plus GbE, UL 62368-1
Nuvo-9002E : NUVO-9000 with single-slot PCIe Cassette, 2.5GbE plus GbE
Nuvo-9002E-UL : NUVO-9000 with single-slot PCIe Cassette, 2.5GbE plus GbE, UL 62368-1
Nuvo-9002LP : NUVO-9000 with hot-swap 2.5" drive tray, 2.5GbE plus GbE
Nuvo-9002LP-UL : NUVO-9000 with hot-swap 2.5" drive tray, 2.5GbE plus GbE, UL 62368-1
Nuvo-9002P : NUVO-9000 with single-slot PCI Cassette, 2.5GbE plus GbE
Nuvo-9002P-UL : NUVO-9000 with single-slot PCI Cassette, 2.5GbE plus GbE, UL 62368-1
Nuvo-9006DE : NUVO-9000 with dual-slot PCIe Cassette, 5x 2.5GbE plus GbE, PoE+ option
Nuvo-9006DE-UL : NUVO-9000 with dual-slot PCIe Cassette, 5x 2.5GbE plus GbE, PoE+ option, UL 62368-1
Nuvo-9006E : NUVO-9000 with single-slot PCIe Cassette, 5x 2.5GbE plus GbE, PoE+ option
Nuvo-9006E-UL : NUVO-9000 with single-slot PCIe Cassette, 5x 2.5GbE plus GbE, PoE+ option, UL 62368-1
Nuvo-9006LP : NUVO-9000 with hot-swap 2.5" drive tray, 5x 2.5GbE plus GbE, PoE+ option
Nuvo-9006LP-UL : NUVO-9000 with hot-swap 2.5" drive tray, 5x 2.5GbE plus GbE, PoE+ option, UL 62368-1
Nuvo-9006P : NUVO-9000 with single-slot PCI Cassette, 5x 2.5GbE plus GbE, PoE+ option
Nuvo-9006P-UL : NUVO-9000 with single-slot PCI Cassette, 5x 2.5GbE plus GbE, PoE+ option, UL 62368-1
  • CPU: Intel Pentium G Series Alder Lake, Intel Core 12th Gen Alder Lake, Intel Core 13th Gen Raptor Lake, Intel Celeron G Series Alder Lake
  • GPU / AI Accelerator: Discrete GPU (PCIe)
  • GPU: NVIDIA RTX PRO 2000 Blackwell, NVIDIA RTX PRO 4000 Blackwell SFF, NVIDIA RTX 2000E Ada
  • AI Performance: 142–770 TOPS
  • Memory: 2x DDR5 4800MHz SO-DIMM Slot, 64GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 1x Display Port, 1x DVI, 1x VGA
  • Ethernet: 1x GbE LAN [RJ45], 5x 2.5 GbE LAN [RJ45]
  • USB: 1x USB 3.2 Gen 2x2 [Type C], 2x USB 2.0 [Type A], 2x USB 3.2 Gen 1 [Type A], 4x USB 3.2 Gen 2 [Type A]
  • Serial: 2x RS232 [DB9], 2x RS232/422/485 [DB9]
  • M.2: 1x M.2 B-Key [PCIe x1/USB/SIM] [3042/3052], 1x M.2 M-Key [PCIe x4 Gen4] [2280]
  • mPCIe: 1x mPCIe [PCIe/USB]
  • PCIe: 1x PCIe [x16 Slot] [x16 Signal] [Gen3]
  • Storage: 1x M.2 SSD [M-Key 2280, PCIe Gen 4 x4], 2x 2.5" HDD/SSD [SATA]
  • RAID: RAID 0, RAID 1
  • Power: 8-48V DC [Terminal Block]
  • Temp: -25°C to 60°C [-13°F to 140°F]
  • Certification: CE, FCC
  • Mounting Options: Wall Mount
  • CPU: Intel Pentium G Series Alder Lake, Intel Core 12th Gen Alder Lake, Intel Core 13th Gen Raptor Lake, Intel Celeron G Series Alder Lake
  • GPU / AI Accelerator: Discrete GPU (PCIe)
  • GPU: NVIDIA L4
  • AI Performance: 485 TOPS
  • Memory: 2x DDR5 4800MHz SO-DIMM Slot, 64GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 1x Display Port, 1x DVI, 1x VGA
  • Ethernet: 1x GbE LAN [RJ45], 5x 2.5 GbE LAN [RJ45]
  • USB: 1x USB 3.2 Gen 2x2 [Type C], 2x USB 2.0 [Type A], 2x USB 3.2 Gen 1 [Type A], 4x USB 3.2 Gen 2 [Type A]
  • Serial: 2x RS232 [DB9], 2x RS232/422/485 [DB9]
  • M.2: 1x M.2 B-Key [PCIe x1/USB/SIM] [3042/3052], 1x M.2 M-Key [PCIe x4 Gen4] [2280]
  • mPCIe: 1x mPCIe [PCIe/USB]
  • PCIe: 2x PCIe [x16 Slot] [x8 Signal] [Gen3] [Cassette]
  • Storage: 1x M.2 SSD [M-Key 2280, PCIe Gen 4 x4], 2x 2.5" HDD/SSD [SATA]
  • RAID: RAID 0, RAID 1
  • Power: 8-48V DC [Terminal Block]
  • Temp: -25°C to 60°C [-13°F to 140°F]
  • Mounting Options: Wall Mount
  • Certification: CE, FCC
COMPARE VARIANTS
Select Nuvo-9166GC Variant
Nuvo-9166GC : Nuvo-9166GC with NVIDIA L4, second PCIe slot, 8 V to 48 V DC
Nuvo-9166GC-UL : Nuvo-9166GC with NVIDIA L4, dual PCIe slots, 24 V DC input and UL 62368-1
  • CPU: Intel Core Ultra Series 2 Arrow Lake-S
  • GPU / AI Accelerator: Intel NPU
  • AI Performance: 13 TOPS
  • Memory: 2x DDR5 6400MHz SO-DIMM Slot, 64GB
  • OS: Linux, Windows 10, Windows 11
  • Serial: 2x RS232 [DB9], 2x RS232/422/485 [DB9]
  • mPCIe: 2x mPCIe [PCIe/USB]
  • RAID: RAID 0, RAID 1
  • Power: 8-48V DC [Terminal Block]
  • Ignition Sensing: Supports Ignition Control
  • Certification: CE, EN55032, FCC
  • Mounting Options: DIN Mount, Wall Mount
  • Display Outputs: 1x Display Port, 2x HDMI
  • Ethernet: 1x 2.5 GbE LAN [RJ45], 1x GbE LAN [RJ45]
  • USB: 2x USB 3.2 Gen 1 [Type A], 2x USB 3.2 Gen 2 [Type A], 4x USB 2.0 [Type A]
  • PCIe: 1x PCIe [x16 Slot] [1x16 Signal or 2x8 Signal] [Gen4]
  • Storage: 2x 2.5" HDD/SSD [SATA]
  • Temp: -25°C to 70°C [-13°F to 158°F]
COMPARE VARIANTS
Select Nuvo-11000 Variant
Nuvo-11002E : NUVO-11000 with single-slot PCIe Gen4 x16 Cassette, 2.5GbE plus GbE
Nuvo-11002LP : NUVO-11000 with hot-swap 2.5" drive tray, 2.5GbE plus GbE
Nuvo-11006DE : NUVO-11000 with dual-slot PCIe Cassette, 6 LAN ports, PoE+ and 10GbE options
Nuvo-11006E : NUVO-11000 with single-slot PCIe Cassette, 6 LAN ports, PoE+ and 10GbE options
Nuvo-11006LP : NUVO-11000 with hot-swap 2.5" drive tray, 6 LAN ports, PoE+ and 10GbE options
  • CPU: Intel Core Ultra Series 2 Arrow Lake-S
  • GPU / AI Accelerator: Discrete GPU (PCIe)
  • AI Performance: 13 TOPS
  • Memory: 2x DDR5 6400MHz SO-DIMM Slot, 64GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 1x HDMI, 2x Display Port
  • Ethernet: 1x GbE LAN [RJ45], 5x 2.5 GbE LAN [RJ45]
  • USB: 1x USB 2.0 [Type A], 8x USB 3.2 Gen 2 [Type A]
  • Serial: 2x RS232 [DB9], 2x RS232/422/485 [DB9]
  • M.2: 1x M.2 M-Key [PCIe x4 Gen5] [2280]
  • mPCIe: 2x mPCIe [PCIe/USB]
  • PCIe: 1x PCIe [x16 Slot] [1x16 Signal or 2x8 Signal] [Gen4]
  • Storage: 1x M.2 SSD [PCIe], 2x 2.5" HDD/SSD [SATA]
  • RAID: RAID 0, RAID 1
  • Power: 8-48V DC [Terminal Block]
  • Temp: -25°C to 60°C [-13°F to 140°F]
  • Certification: CE, EN55032, FCC
  • Mounting Options: Wall Mount
  • CPU: Intel Atom X Series Alder Lake
  • Memory: 1x DDR5 4800MHz SO-DIMM, 16GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 2x HDMI
  • USB: 2x USB 3.2 Gen 1 [Type A], 2x USB 3.2 Gen 2 [Type A]
  • Serial: 1x RS422/485 [DB9], 1x RS232/422/485 [DB9], 3x RS232 [DB9]
  • M.2: 1x M.2 M-Key [SATA] [2280]
  • Storage: 1x M.2 SSD [SATA]
  • Power: 8-35V DC [Terminal Block]
  • Temp: -25°C to 70°C [-13°F to 158°F]
  • Certification: CE, FCC
  • Mounting Options: DIN Mount, Wall Mount
  • Ethernet: 1x 2.5 GbE LAN [RJ45], 2x 2.5 GbE LAN [RJ45] [PoE]
COMPARE VARIANTS
Select POC-600 Variant
POC-600 : POC-600 with Intel Atom x7425E, 3x 2.5GbE including 2x PoE+ and DIN-rail mount
POC-610 : POC-600 with Intel Atom x7425E, 3x 2.5GbE without PoE and DIN-rail mount
  • Memory: 1x DDR5 4800MHz SO-DIMM, 16GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 1x Display Port, 1x HDMI
  • USB: 4x USB 3.2 Gen 2 [Type A]
  • Serial: 1x RS232/422/485 [DB9], 3x RS232 [DB9]
  • M.2: 1x M.2 M-Key [PCIe x1/SATA] [2280]
  • mPCIe: 1x mPCIe [PCIe/USB/SIM]
  • Storage: 1x M.2 SSD [PCIe & SATA]
  • Ignition Sensing: Supports Ignition Control
  • Temp: -25°C to 70°C [-13°F to 158°F]
  • Mounting Options: DIN Mount, Wall Mount
  • CPU: Intel Processor N Series Alder Lake
  • Ethernet: 4x GbE LAN [RJ45] [PoE]
  • Power: 8-35V DC [Terminal Block]
  • Certification: CE, FCC
COMPARE VARIANTS
Select POC-700 Variant
POC-712 : POC-700 with Intel Atom x7425E, 4x GbE and 4x USB 3.2 Gen2
POC-712-UL : POC-700 with Intel Atom x7425E, 4x GbE, UL 62368-1 certified
POC-715 : POC-700 with Intel Core i3-N305, 4x GbE PoE+ and 4x USB 3.2 Gen2
POC-715-UL : POC-700 with Intel Core i3-N305, 4x GbE PoE+, UL 62368-1 certified
  • Memory: 1x DDR5 4800MHz SO-DIMM, 16GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 1x Display Port, 1x HDMI
  • USB: 4x USB 3.2 Gen 2 [Type A]
  • Serial: 1x RS232/422/485 [DB9], 3x RS232 [DB9]
  • M.2: 1x M.2 M-Key [PCIe x1/SATA] [2280]
  • mPCIe: 1x mPCIe [PCIe/USB/SIM]
  • Storage: 1x M.2 SSD [PCIe & SATA]
  • Power: 8-35V DC [Terminal Block]
  • Ignition Sensing: Supports Ignition Control
  • Temp: -25°C to 60°C [-13°F to 140°F]
  • Certification: CE, FCC
  • Mounting Options: Wall Mount
  • CPU: Intel Processor N Series Alder Lake
  • Ethernet: 4x GbE LAN [RJ45] [PoE]
COMPARE VARIANTS
Select POC-700-FT Variant
POC-712-FT : POC-700-FT with Intel Atom x7425E, 4x GbE and flattop heatsink
POC-715-FT : POC-700-FT with Intel Core i3-N305, 4x GbE PoE+ and flattop heatsink
  • CPU: AMD Ryzen PRO 8000 Series
  • GPU / AI Accelerator: AMD Ryzen AI NPU
  • AI Performance: 16 TOPS
  • Memory: 1x DDR5 5600MHz SO-DIMM Slot, 32GB
  • OS: Linux, Windows 10, Windows 11
  • Display Outputs: 2x HDMI
  • Ethernet: 4x GbE LAN [RJ45] [PoE]
  • USB: 4x USB 3.2 Gen 2 [Type A]
  • Serial: 1x RS232/422/485 [DB9], 3x RS232 [DB9]
  • M.2: 1x M.2 M-Key [PCIe x4] [2280]
  • mPCIe: 1x mPCIe [PCIe/USB/SIM]
  • Storage: 1x M.2 SSD [PCIe]
  • Power: 8-35V DC [Terminal Block]
  • Temp: -25°C to 70°C [-13°F to 158°F]
  • Certification: IEC 62368-1, CE, EN55032, FCC, UL 62368-1
  • Mounting Options: DIN Mount, Wall Mount

Official Neousys UK Distributor

Things Embedded is an official Neousys UK distributor, supplying the MezIO-C181-50 fitted inside the Neousys computer, with port modes and termination set and the build tested before it ships. Where a Nuvo-9000 system needs isolated digital I/O on its MezIO interface rather than serial, the MezIO-D230/D220 series adds 16 or 32 isolated channels.

Across our range, the MezIO-C181-50 sits with our MezIO expansion modules and our industrial I/O and data acquisition products, alongside hosts such as the POC-900.

Consult. Design. Integrate.

Things Embedded is a leading UK supplier of industrial computing and edge AI systems. We combine technical expertise with a collaborative approach to deliver optimal solutions for your application. Whether it’s an off-the-shelf platform or a custom design, we stay at the forefront of the latest technologies to ensure your success at the edge. Our team works closely with you from concept through deployment, providing guidance, engineering support, and integration expertise every step of the way.

Connect with our solutions experts today to review your requirements and find the ideal solution fit for your application.