The Short Answer
RS-422 was designed to extend serial links beyond the short reach of RS-232. Because it compares two wires rather than measuring against ground, interference cancels out. RS-485 builds on the same idea but allows many transmitters on one bus, which RS-422 does not.
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Long cable runs Linking equipment across a plant or yard.
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Noisy environments Near motors, drives and heavy machinery.
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One-to-many broadcast A controller sending to several displays or devices.
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Full-duplex links Simultaneous send and receive on separate pairs.
Why It Matters
Our RS-232 vs RS-485 FAQ compares all three standards, and the British Steel case study shows protocol-selectable RS-232/422/485 on rugged panel PCs. See our rugged panel PCs.