The Short Answer
Both move materials without a driver. AGVs are predictable and well suited to repetitive routes in stable layouts; AMRs are more flexible where layouts and traffic change. Either way, the onboard computer decides how well the vehicle sees and reacts to what is around it.
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Guidance AGVs follow infrastructure on the floor; AMRs navigate from what their sensors see.
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Flexibility AMRs adapt to new layouts without re-installing guidance.
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Obstacles AMRs route around them; AGVs wait or stop.
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Compute AMRs need more onboard processing for perception and planning.
Why It Matters
Real-time AI on the vehicle closes much of the gap: even fixed-route vehicles benefit from seeing pedestrians and changing layouts. Our smart factory case study shows rugged fanless Jetson computers running that inference on material handling vehicles, and our edge AI computers cover the range.